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During recycling, arsine can be released if scrap containing arsenic is melted down with the “maintenance-free” batteries containing calcium. Exchange transfusions lower blood arsenic levels, but dialysis, though it may be life-saving, does not remove arsenic from the patient. Chemical Formula: AsH 3, Arsine Bulmer, F.M.R., H.E. 2012;29(1):85-93. The water reacted with the arsenide of the alkali metal, generating arsine. Stibine (SbH3; hydrogen antimonide; antimony hydride; antimony trihydride)- Antimony (Sb) can be converted to stibine by a similar series of reactions required to convert arsenic to arsine. arsenic by humans has been linked to a form of skin cancer and also to bladder, liver, and lung cancer. Arsine fumes were generated by moisture reacting with aluminum arsenide in metal dross. Initial symptoms of arsine poisoning are headache, malaise, weakness, dizziness difficult breathing, abdominal pain, nausea, and vomiting, which are usually first noticed 2 to 24 hours after exposure. 2007 May;23(4):183-208. doi: 10.1177/0748233707076810. Arsine: Human health aspects. The above information was obtained from the National Institute for Occupational Safety and Health’s computerized Registry of Toxic Effects of Chemical Substances (RTECS), and from the National Library of Medicine’s computerized chemical dictionary file CHEMLINE. A detailed history to determine the exposure includes the following: 1. As cooling occurs, the calcium arsenide floats to the surface as part of the dross, and in the presence of water, arsine evolves.20. Anthony Robbins, M.D. Properties, occurrence, and chemistry of arsine formation were presented. The first signs of arsenic toxicity are large amounts of "rice water" diarrhea that may be bloody, along with … Apparently, the copper in this mixture was contaminated with arsenic. Arsenic as a solute is nearly tasteless and can present in contaminated drinking water; it is also documented as a method of intentional homicide and suicide. Clinical effects of arsenic toxicity depend on the chronicity of exposure (eg, acute, chronic) and the chemical form involved, which may be inorganic arsenic (pentavalent arsenic and trivalent arsenic), organic arsenicals, or arsine gas. 2016 Feb 15;13(2):215. We request that producers and distributors of arsenic and materials containing arsenic transmit information to their customers and employees, and that professional associations and unions inform their members. TABLE 2. Ind, G. Kazantzis, and R. Owens: Arsine Poisoning: Massive Hemolysis with Minimal Impairment of Renal Function. Three workers were poisoned while using a jackhammer to remove slag from ladles. CDC twenty four seven. Before assigning the trailer to another client, a thorough cleaning job was ordered, which required the hand application of the acid cleaner. Subsequently the mixture of water and sodium arsenite under these conditions led to the generation of arsine. Arsenate can replace phosphate in many reactions. 1979 Oct;40(10):A56-61. Arsine, the most toxic form of arsenic, is often produced from the reduction of inorganic arsenic salts with the use of acids and metal cofactors such as zinc. (1946), 1, 287. The acidic arsenic liquor reacted with the zinc coating of the bucket and produced arsine. In most situations where arsine can be formed stibine can also be formed if antimony is present. Probably because of this instability fewer cases of stibine poisoning have been reported.22 Stibine can evolve when certain alloys containing antimony (Sb) are treated with acid and subjected to electrolytic action, when certain antimony compounds are treated with steam, or whenever nascent hydrogen comes in contact with metallic antimony or with a soluble antimony compound. A) USES: Arsine (AsH. 2014 Sep;47(5):253-7. doi: 10.3961/jpmph.14.036. The exact mechanism by which arsenic causes erythrocytes to In all occupational settings where there is arsenic, workers should be informed of the possibility of arsine formation when there is nascent (freshly formed) hydrogen present. Stock.. A., and O. Guttmann: On Stibine and Yellow Antimony. From 1815 to 1928, 247 cases of arsine poisoning were reported. EPA has classified inorganic arsenic as a human carcinogen. -, Carlin DJ, Naujokas MF, Bradham KD, Cowden J, Heacock M, Henry HF, Lee JS, Thomas DJ, Thompson C, Tokar EJ, Waalkes MP, Birnbaum LS, Suk WA. To reduce dust, water was sprayed on the slag. The exposed victims experienced shortness of breath on exertion, and a general feeling of weakness. Further research on the chronic and acute effects of exposure to arsine and stibine is needed. This site needs JavaScript to work properly. Case Reports – Most cases of arsine poisoning occur after the accidental generation of the gas in the workplace. Although the acute toxicity of arsine in humans is fairly well defined, very little information is available on long term effects of exposure to arsine with simultaneous exposure to other arsenic compounds. Exposure also may occur from producing, cleaning, or reclaiming gallium arsenide wafers. Male 5-week-old Hos:HR-1 hairless mice were subjected to a single percutaneous exposure or whole-body inhalation exposure of ca. Arsine is a colorless, flammable, non-irritating toxic gas with a mild garlic odor. The toxicity of arsine is distinct from that of other arsenic compounds. Rothwell, S.S. Polack, and D.W. Stewart: Chronic Arsine Poisoning Among Workers Employed in the Cyanide Extraction of Gold: A Report of Fourteen Cases. -. Therefore, efforts should be made to remove arsenic from the victim’s body.25 Other medical support measures should be utilized as indicated. Elkins, H.B., and J.P. Fahy: Arsine Poisoning from Aluminum Tank Cleaning. When ingested arsenic compounds can cause nausea, vomiting and diarrhea within a few hours. In the production of “maintenance-free” batteries, calcium is added to the lead alloys as a hardening agent. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Although arsenic homicides commonly receive media publicity, the primary source of arsenic toxicity to the general population is by contaminated water, soil and food products. Lead alloys in car batteries contain antimony as a hardener, with arsenic and silver added to inhibit corrosion. Acute Arsine Toxicity – Arsine is the most acutely toxic form of arsenic and one of the major industrial causes of sudden extensive hemolysis (destruction of red blood cells). However, in relation to the degree of blood destruction, the degree of known disability experienced by the victims of chronic arsine poisoning was less than expected.8, Chronic Arsenic Toxicity – Since inorganic arsenic is needed to generate arsine, prolonged exposures to low levels of arsine are likely to occur under conditions where workers are also exposed to inorganic arsenic. The Mean Lethal Dose (MLD) is unknown for man, but in small mammals it is about 0.5 mg/kg body weight.6, The characteristic features of acute arsine poisoning are abdominal paint bloody urine, and jaundice (yellow discoloration of the skin). Skin cancer has long been considered a consequence of arsenic exposure, however multiple cancers of the internal organs have also been reported.3.  |  What is Arsine 4. This was manifested by a progressive drop in the number of red blood cells and in the hemoglobin level. NLM Arsine usually evolved when nascent hydrogen was generated in the presence of arsenical compounds or by the hydrolysis of a metallic arsenide in contact with water. Environmental source of arsenic exposure. These chemicals reacted to produce nascent hydrogen, which bonded with the arsenic, leading to generation of arsine. 2014 Sep;47(5):245-52. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. COVID-19 is an emerging, rapidly evolving situation. [signature] Rev Environ Contam Toxicol. Arsenous hydride In addition more research into methods of sampling for the presence of arsine and stibine in air is needed, for both monitoring and documentation purposes. Although the accidents illustrated in the above tables differ with respect to the surrounding circumstances, the basic reactions leading to arsine formation are similar. Mann, N.N. Environ Health Perspect. A number of signs and symptoms are associated with arsenic poisoning. of arsenic compounds to arsine is the primary mechanism for gaseous loss of arsenicals from solid. Arnold: Arsine Poisoning. Int J Environ Res Public Health. CAS number: 7784-42-1 NIOSH REL: 0.002 mg/m3 15-minute CEILING; NIOSH considers arsine to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. Arsenic exposure is usually associated with suicide, malicious intent, homicide, or occupational exposure. Jenkins, G.C., J.E. Arsine (arsenic hydride) poisoning in the workplace. This estimate is not, however, based on actual workplace environmental exposure measurements. Changes in the heart’s performance as measured by the electrocardiogram (ECG) have been reported after chronic arsenic intoxication. 3rd ed., Volumes 1-26. Inorganic arsenic exposure of humans, by the inhalation route, has been shown to be strongly associated with lung cancer, while ingestion of inorganic arsenic by humans has been linked to a form of skin cancer and also to bladder, liver, and lung cancer. 2004 Nov 04;124(21):2750-3. Careful history regarding dietary and nutritional habits (eg, use of nutritional supplements and ayurvedic medicines, alcohol abuse) and hobbies Clinical effects of arsenic toxicity depend on the chronicity of exposure (eg, acute, chronic) and the chemical form involved, whic… Observed ECG changes regressed after arsenic exposure ceased. Therefore, similar work practices should be implemented to reduce the risk of worker exposure to stibine. 1. Therefore, some of the above synonyms and identifiers may be trademarked but are not so indicated above. Hawlick, G.F., and E.B. [Arsenic poisoning]. Arsine, ook bekend als arseentrihydride, is een bijzonder toxisch gas met als brutoformule AsH3, dat onder andere gebruikt wordt voor de synthese van halfgeleiders en forensisch onderzoek. Reed: Industrial Arsine Poisoning: Report of Three Cases. DePalma, A.E. Readily absorbed via GI tract and inhalation, poorly via skin Thirteen workers were poisoned (3 died) during the purification of lead alloys. Inorganic arsenic is found in nature at low levels mostly compounded with oxygen, chlorine, and sulfur. Most of the reported cases occurred when arsine was accidently generated during an industrial process. Two workers were poisoned after a commercial drain cleaner was added to a drain which contained water and arsenic residues. You will be subject to the destination website's privacy policy when you follow the link. Brit. Chemical Abstracts Service Registry Number: 7784-42-1 Unpublished Report. Indian J Dermatol Venereol Leprol. Pinto, S.S., S.J. Arsenic trioxide is now used to treat acute … Stibine equals or surpasses arsine in toxicity, and causes a specific toxic action which closely resembles that of arsine.21 Although stibine is chemically similar to arsine, it is less stable. Dermatitis may be observed after chronic ingestion but the typical signs include increased pigmentation, and thickening of the skin on the palms and soles of the feet. Examples of workers poisoned by arsine in smelting and refining operations. Arsenic poisoning is a global health issue affecting millions of people worldwide through environmental and occupational exposure, as well as intentional suicide and homicide attempts. Putman: Arsine Poisoning Country Style. Whenever the possibility exists for either gas being generated, such as when working with metals (crude, drosses, or implements made of metal) care should be taken to assure that arsenic and antimony do not react with any sources of fresh hydrogen. Mechanism. The National Institute for Occupational Safety and Health (NIOSH) recommends that appropriate work practices be implemented to reduce the risk of worker exposure to arsine (AsH3) gas, There is a high potential for the generation of arsine gas when inorganic arsenic is exposed to nascent (freshly formed) hydrogen. In one report of chronic arsine poisoning, it was noted that arsine in very small concentrations appeared to exert a cumulative, damaging effect. Wilkinson, S.P., P. McHugh, S. Horsley, H. Tubbs, M. Lewis, A. Thould, M. Winterton, V. Parsons, and R. Williams: Arsine Toxicity Aboard the Asia Freighter. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. The present OSHA standard for occupational exposure to stibine to 0.1 ppm (0.5 mg/cu m of air) in any 8-hour work shift of a 40-hour work week.2 The 1975 NIOSH Criteria Document on inorganic arsenic recommended that worker exposure to inorganic arsenic and to arsine be limited to 0.002 mg (2.0 µ) of arsenic/cu m of air as determined by a 15-minute sampling period. In light of the serious and accidental nature of exposure to arsine and/or stibine, NIOSH recommends that steps be taken to prevent exposure to these gases. Frequently, patients exposed to arsenic have a garlic odor to their breath and tissue fluids. From 1928 to 1974 an additional 207 cases were reported, of which 51 (25%) were fatal.1, Acute Arsine Toxicity – Arsine is the most acutely toxic form of arsenic and one of the major industrial causes of sudden extensive hemolysis (destruction of red blood cells). HHS Secondary effects resulting from haemolysis include haemolytic anaemia, hepatic and renal damage. Current OSHA PEL: 0.05 ppm (0.2 mg/m3) TWA 1989 OSHA PEL: Same as current PEL 1993-1994 ACGIH TLV: 0.05 ppm (0.16 mg/m3) TWA Description of substance: Colorless gas with a mild, garlic … The worker’s risk of arsenic poisoning is therefore increased by the combination of inorganic arsenic exposure and the breakdown of arsine. Abstract. Kipling, M.D., and R. Fothergill: Arsine Poisoning in a Slag-Washing Plant. Eight children and one adult were poisoned on a farm while cleaning a dipping vat. During recent years of may incidents have involved a reaction between arsenic and aluminum, with the subsequent release of hydrogen in the presence of water to permit the formation of arsine gas.9 Tables 1, 2, and 3 list examples of accidental arsine poisoning reported in the literature. It is used in smelting operations, organic synthesis, the microelectronics industry, and less frequently for … CONTENTS. In: StatPearls [Internet]. 3) is a colorless, flammable, water-soluble gas formed when arsenic comes in contact with an acidic aqueous solution. Arsenic hydride Goncharenko, L.Ye., O.I. Likewise, workers exposed to antimony compounds should be informed of the possibility of exposure to stibine when freshly formed hydrogen is present. Arsenic (As) is a nearly tasteless odorless toxic metalloid element that is found ubiquitously in the environment. Treasure Island (FL): StatPearls Publishing; 2020 Jan. Toxicol Ind Health. 300 ppm arsine for 5 min. Most cases of arsine poisoning have been associated with the use of acids and crude metals, one or both of which contained arsenic as an impurity. Arsine is a gaseous chemical compound that originates from the combination of arsenic and hydrogen atoms. Arsine was generated by reducing arsenic trioxide with NaBH₄. It is soluble in water, and slightly soluble in alcohol and alkalies. The examination was performed 0-6 hr after the exposure. 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Odorless toxic metalloid element that forms a number of poisonous compounds formed if antimony present.

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